\n\nNear-poor elders enrolled in plans with caps or coverage gaps, including Part D plans, may face sharp declines in utilization when they exceed these thresholds.”
“Background & Objectives In recent years, emerging transcatheter aortic valve implantation (TAVI) has become an alternative for surgery. However, with advanced age, several co-morbid factors together with contrast agent usage

can cause deterioration in renal function and increase www.selleckchem.com/products/BMS-777607.html in the risk of acute kidney injury (AKI) with poor prognosis in patients with AKI. Therefore, many patients cannot benefit from this treatment. In this study, we aim to examine the effects of TAVI on renal functions. Methods and Results Seventy patients, mean age of 77.6 years, underwent TAVI between July 2011 and SBI-0206965 inhibitor December 2012. Estimated glomerular filtration rate (eGFR) was calculated by using the Cockcroft and Gault Formula. Patients were monitored for 48 h for urine output. Stage 1 AKI, according to the VARC-2 AKIN system, developed in only five

(7.1%) of the patients after the procedure. There was a statistically significant increase between the mean 1st month eGFRs before (68.2 vs. 61.0, P < 0.01) and after (68.2 vs. 63.6, P < 0.05) the TAVI in the cohort. After TAVI (48.5 mL/min, P < 0.01) and the 1st month (52.1 mL/min, P < 0.01), the eGFR of the 36 (51.4%) patients diagnosed with chronic kidney disease before the procedure showed a statistically AS1842856 cell line significant increase in renal functions. The hospital mortality rate was higher in the group which developed AKI (P < 0.01). First

month eGFR showed a more statistically significant increase than pre-TAVI eGFR (62.8 and 69.8, P < 0.05, respectively) in AKI developing patients and this difference – though statistically not significant – continued into the sixth month. Conclusions In this study, we showed that the treatment of aortic stenosis through TAVI allows improvement of renal functions, and that AKI rates will be lower with careful patient selection, proper pre-procedural hydration, and careful use of contrast agent.”
“The amine fluoride (AmF) N’-octadecyltrimethylendiamine-N, N,N’-tris(2-ethanol)-dihydrofluoride is a cationic antimicrobial which can have beneficial effects on plaque formation. Here, we determine changes in pellicle and bacterial cell surface properties of the strains Actinomyces naeslundii HM1, Streptococcus mutans NS, S. mutans ATCC 700610, S. sobrinus HG1025 and S. oralis HM1 upon adsorption of this AmF and accompanying effects on bacterial adhesion and biofilm growth. In vitro pellicles had a zeta potential of -12 mV that became less negative upon adsorption of AmF. The chemical functionalities in which carbon and oxygen were involved changed after AmF adsorption and AmF-treated pellicles had a greater surface roughness than untreated pellicles.

Sham groups were injected with cerebrospinal fluid using the same procedure. Brains were removed and sectioned to study the mRNA expression using in situ hybridization (ISH).\n\nResults: The main results are the postpubertal onset of increased NR1 mRNA expression in all cortical regions and decreased dopamine D2 receptor, substance P and enkephalin mRNA expression in the striatum only in rats lesioned as neonates. These changes were not observed in the adult group with VH lesion.\n\nConclusions: Our results demonstrate that the postpubertal behavioral changes in this animal model (and possibly schizophrenia)

are related find more to postpubertal onset of changes in the development of functions and interactions of p38 MAP Kinase pathway the dopamine and glutamate receptors in the mesocortical system. (C) 2009 Elsevier B.V. All rights reserved.”
“The hydrodynamic performance of aqueous dextran solutions, including the rheological and thixotropic properties, were investigated. Three kinds of dextrans with different molecular weights were employed to examine the effects of the molecular weight, concentration, temperature, and so forth on the hydrodynamic properties of aqueous dextrin solutions. The results showed that an aqueous solution of a dextran with a high molecular weight of 5.223 x 10(5) at a high concentration of 30 wt % had pseudoplastic properties, in contrast to

the conclusions of other researchers finding that aqueous dextran solutions were Newtonian liquids. The viscosity of the aqueous dextran solutions decreased with temperature, and the activation energy was calculated to be 16,849.2 J/mol with a 70 wt % dextrin ALK targets (weight-average molecular weight = 5.223 x 105) solution. (c) 2008 Wiley Periodicals, Inc. J Appl Polym Sci 111: 1523-1529, 2009″
“An adult alpaca was presented because of abdominal pain and was diagnosed with an intestinal obstruction. The putative diagnosis at surgery was an intestinal obstruction caused

by peritonitis and intra-abdominal adhesions. The cause of the inflammation was not determined at that time. The alpaca died soon after surgery from post-surgical complications and a peritoneopericardial diaphragmatic hernia that was not diagnosed until necropsy.”
“A gold-catalyzed oxidative reaction of propargylic carbonates or acetates using 3,5-dichloropyridine as the oxidant has been developed. The reaction provides efficient access to alpha-functionalized-alpha,beta-unsaturated ketones with excellent regio- and diastereocontrol via a regioselective attack of the N-oxide to the gold-activated alkyne followed by a 1,2-carbonate migration. In addition, the alkene products could be further transformed into the valuable 5-hydroxycyclopent-2-enones via cyclocondensation with acetone or cyclodimerization under basic conditions.”
“Motivated by problems in conservation biology we study genetic dynamics in structured populations of diploid organisms (monoecious or dioecious).

This study aimed to identify proteins produced by B-30929 in response to environmental EtOH. Cellular proteins expressed by B-30929 growing inmedia with 10 versus 0% EtOH were compared by 2DE, followed by in-gel digestion and MALDI-MS analyses. Twenty EtOH responsive proteins were identified. These include a proline-specific peptidase (Lbuc_1852); a membrane protein (Lbuc_0921), two general stress-related proteins including a 10 kDa chaperonin (GroESL Lbuc_1359) and a 29 kDa member of the HK 97 family (Lbuc_1523); metabolic enzymes involving redox potential balances (Lbuc_2051 and Lbuc_0522) and carbohydrate fermentation (Lbuc_1319 and Lbuc_2157); nitrogen, amino acid, and fatty acid

metabolism proteins (Lbuc_1994, Lbuc_0446, Lbuc_0858, Lbuc_0707, and Lbuc_0787). These changes suggested B-30929 cells respond to MK-8776 EtOH by degradation of available proteins and fatty acids and increased production of specific enzymes and molecular chaperons. These results can be used to guide genetic modifications to increase EtOH tolerance in industrial biocatalysts. The data have been deposited to World-2DPAGE (http://world-2dpage.expasy.org/repository/0068/; username liu, password 1h8d6Mg1).”
“Ethnic differences in renal calcium and phosphate excretion exist, which may depend on differences in their

dietary intakes and regulatory factors. We report highly significant differences AS1842856 research buy in urinary calcium and phosphate excretion between white British and Gambian adults after statistical adjustment for mineral intakes, indicating an independent effect of ethnicity. Introduction Populations vary in their risk of age-related osteoporosis. There are racial or ethnic differences in the metabolism of the bone-forming minerals calcium (Ca) and phosphate (P), with a lower renal Ca and P excretion in African-Americans compared to white counterparts, even at similar intakes and rates of

absorption. Also, Africans in The Gambia have a lower Ca excretion compared to white British subjects, groups known to differ in their dietary Ca intake. Here, we report on differences in urinary Ca and P excretion between Gambian and white British adults while allowing for known predictors, including dietary intakes. Methods Participants were healthy white British (n = 60) and Gambian (n = 61) men and women aged 60-75 years. Fasting blood and 2-h urine samples ABT-263 cell line were collected. Markers of Ca and P metabolism were analysed. Dietary intake was assessed with country-specific methods. Results White British older adults had higher creatinine-corrected urinary Ca and P excretion (uCa/uCr, uP/uCr) and lower tubular maximum of Ca and P compared to Gambian counterparts. The predictors of urinary Ca and P differed between groups. Multiple regression analysis showed that dietary Ca and Ca/P were predictors of uCa/uCr and uP/uCr, respectively. Ethnicity remained a significant predictor of uCa/uCr and uP/uCr after adjustment for diet and other factors.

(C) 2007 Elsevier Inc. All rights reserved.”
“Malignant catarrhal

fever (MCF), a frequently fatal herpesviral disease primarily of ruminant species, has been sporadically reported in pigs. All cases of naturally occurring porcine MCF reported to date have been linked to ovine herpesvirus 2 (OvHV-2), a gammaherpesvirus in the genus Macavirus carried by sheep. Experimental Linsitinib datasheet induction of MCF by aerosolization of the virus in nasal secretions collected from infected sheep has been successful in bison, cattle and rabbits. The goals of this study were to determine the susceptibility of pigs to MCF following experimental intranasal inoculation of OvHV-2, and to characterize the disease. Twelve pigs in four groups were nebulized with 10(5), 10(6), 10(7), or 10(8) DNA copies of OvHV-2 from sheep nasal secretions. Three control pigs were nebulized with nasal secretions from uninfected sheep. Three additional pigs were inoculated intravenously with 10(7) DNA copies of OvHV-2 to evaluate this FG-4592 price route of infection with cell-free virus. Seven of twelve intranasally challenged pigs became infected with OvHV-2. Five of these seven, all in higher dose groups, developed MCF. Lesions resembled those reported in natural cases of porcine

MCF. The most striking and consistent histological lesions were in trachea, lung, kidney and brain. These comprised mucopurulent tracheitis, interstitial pneumonia,

necrotizing arteritis-periarteritis, and nonpurulent meningoencephalitis. No infection was established in the intravenously challenged or control groups. The study showed that MCF can be experimentally induced in pigs by aerosol challenge using sheep nasal secretions containing OvHV-2. Domestic pigs are a natural clinically susceptible host for sheep-associated MCF. They represent a useful, cost-effective model for MCF research. Published by Elsevier B.V.”
“The phytochemical study selleck inhibitor of Cordia exaltata Lam. (Boraginaceae) led to the isolation, through chromatographic techniques, of nineteen secondary metabolites: 8,8′dimethyl-3,4,3′, 4′-dimethylenedioxy-7-oxo-2,7′cyclolignan (1), 8,8′-dimethyl-4,5-dimethoxy-3′, 4′-methylenodioxy-7-oxo-2,7′cyclolignan (2), sitosterol (3a), stigmasterol (3b), sitosterol-3-O-beta-D-glucopyranoside (4a), stigmasterol-3-O-beta-D-glucopyranoside (4b), phaeophytin A (5), 13(2)-hydroxyphaeophytin A (6), 17(3)-ethoxypheophorbide A (7), 13(2)-hydroxy-17(3)-ethoxypheophorbide A (8), m-methoxy-p-hydroxybenzaldehyde (9), (E)-7-(3,4-dihydroxyphenyl)- 7-propenoic acid (10), 1-benzopyran-2-one (11), 7-hydroxy-1-benzopyran2- one (12), 2,5-bis-(3′,4′-methylenedioxiphenyl)-3,4-dimethyltetrahydrofuran (13), 3,4,5,3′, 5′-pentamethoxy-1′-allyl-8. O.

Molecular classification of the individual tumors and identification of molecular escape mechanisms for primary (intrinsic) and secondary resistances to KI treatment is critical to select the patients’ most likely to benefit. Appropriate drug combinations based on those mechanisms of resistance have to be tested in selected patient populations to ensure progress and efficacy with the goal to lead

to a clinically meaningful prolongation of patients’ lives.”
“This paper reports on an investigation of interface state densities, low frequency noise and electron mobility in surface channel In0.53Ga0.47As n-MOSFETs with a ZrO2 gate dielectric. Interface state density values of D-it similar to 5 x 10(12) cm(-2) eV(-1) URMC-099 order were extracted using sub-threshold slope analysis and charge pumping technique. The same order of magnitude of trap density was found from low frequency noise measurements. A peak effective electron mobility of 1 200 cm(2)/Vs has

been achieved. For these surface channel In0.53Ga0.47As n-MOSFETs, it was found that eta parameter, an empirical parameter used to calculate the effective electric field, was similar to 0.5 5, and is to be comparable to the standard value found in Si device. (c) 2011 Elsevier B.V. All rights reserved.”
“Introduction\n\nBecause foods fortified with calcium are increasingly available, the calcium content of calcium-fortified foods may not be adequately captured in traditional assessments of dietary intake, such as dietary records analyzed with commercially available software. The primary objective of our study was to design and Epacadostat manufacturer test a calcium-focused food frequency questionnaire (CFFFQ) including foods naturally rich in calcium and calcium-fortified foods. Secondary objectives were to review calcium sources and adequacy of intake in black and in white postmenopausal women.\n\nMethods\n\nWe studied a convenience

sample of 46 black and 139 white postmenopausal women (mean [SD] age 69.4 [5.8] years). Participants completed a multiple-pass interview for 24-hour recall of foods eaten and the 46-item CFFFQ.\n\nResults\n\nThe correlation between measures for total daily calcium intake was moderately strong (r = 0.53, P < .001). The CFFFQ estimated greater total daily calcium intake than did the 24-hour recall (mean [SD], 1,021 [624] Pevonedistat in vitro mg/d vs 800 [433] mg/d, P < .001). As daily calcium intake increased, the 24-hour recall increasingly underreported calcium (r = 0.41, P < .001) compared with the CFFFQ. Cross-tabulation and X-2 analyses found that the CFFFQ had greater specificity for lower calcium intakes. For calcium classified by food groups, there was moderate correlation for dairy (r = 0.56, P < .001) and fruits (r = 0.43, P < .001). The CFFFQ overestimated mean total calcium compared with the 24-hour recall by 221 mg/d (P < .001), including within racial groups (195 mg/d for black women, P = .04, and 229 mg/d for white women, P < .

5 solar spectrum is 18.51% as compared to the reference, and producing a 19.65% improvement in short-circuit current density

(J(SC)) over 11.7 mA/cm(2) for a reference cell. The J(SC) in the nano-disk patterned solar cell (NDPSC) was found to be higher than the commercial reference structure for any incident angle. The NDPSC has a multi-resonant optical response for the visible spectrum and the associated mechanism for OE in i-a-Si:H layer is excitation of Fabry-Perot resonance facilitated by surface plasmon resonances. The detrimental Staebler-Wronski effect in a-Si:H solar cell can be minimized by the additional OE in the NDPSC and self-annealing of defect states by additional heat generation,

Selleck 17DMAG thus likely improving the overall stabilized characteristics of a-Si:H solar cells. (c) 2014 AIP Publishing LLC.”
“Purpose: Carcinosarcoma is a rare malignant tumor of mixed epithelial and mesenchymal origin. In the head and neck, carcinosarcoma most commonly affects the salivary glands. Primary sinonasal carcinosarcoma (SN-CS) is exceedingly rare. Methods: We performed a retrospective analysis of 15 cases of SN-CS obtained from the Surveillance, Epidemiology https://www.selleckchem.com/products/GSK461364.html and End Results (SEER) database from 1973 to 2010. Case-matched cohorts of non-sinonasal carcinosarcoma (NS-CS), salivary gland carcinosarcoma (SG-CS) and carcinosarcoma at all other head and neck sites (NonSNSG-CS) were used for comparison. Results: Women made up 60.0% of the SN-CS cohort and whites 73.3%. Tumors originated in the nasal cavity in 46.7% of cases, and from the maxillary sinus in 33.3%. In 66.7% of cases, tumors were poorly differentiated (histologic grades III and IV). Surgery with radiotherapy was the primary treatment modality in 46.7% of cases. Five-year disease-specific survival (DSS) was 48.5% for SN-CS compared to 65.5% for the case-matched SG-CS cohort (p = 0.2950), whereas it was 76.9% for the VEGFR inhibitor case-matched NonSNSG-CS cohort (p = 0.0406). Conclusion: SN-CS is a rare tumor. Here we present the largest known cohort of SN-CS and report

on its demographic, clinicopathologic and survival features. Our results suggest that patients with SN-CS have DSS comparable to the case-matched cohort of SG-CS patients. However, SN-CS patients have significantly poor survival outcomes compared to the case-matched cohort of NonSNSG-CS patients. (C) 2015 Elsevier Inc. All rights reserved.”
“Understanding the mechanisms underlying distributed pattern formation in brain networks and its content driven dynamical segmentation is an area of intense study. We investigate a theoretical mechanism for selective activation of diverse neural populations that is based on dynamically shifting cellular resonances in functionally or structurally coupled networks.

Results show that glucagon, dose and time dependently, protects against acetaminophen-induced hepatotoxicity. This protection was achieved with a dose of 0.5 mg/kg of glucagon given intraperitoneally 15 min before or 1 h after acetaminophen. Treatment of animals with acetaminophen elevated ALT and nitrite/nitrate concentration

in the plasma, enhanced iNOS and NF-kappa B expression and reduced GSH and cAMP concentration in the liver. Animals treated with glucagon had higher hepatic cAMP level, lower ALT and nitrite/nitrate concentration in plasma and lower expression of iNOS in liver cells than animals in control group, whereas there was no difference in the expression of NF-kappa B. Glucagon did not prevent the loss of GSH content

caused by acetaminophen. Our investigation indicates that glucagon has a moderately protective effect against acetaminophen-induced liver injury, which is, at least partially, mediated through selleck chemical the downregulation Linsitinib price of iNOS and through the increase in hepatic cAMP content, but it is not mediated through the modulation of NF-kappa B activity.”
“The diagnostic accuracy of tuberculosis (TB) remains a clinical challenge, and a number of studies have used the interferon gamma-induced protein 10 (IP-10) in the diagnosis of TB. The aim of the present meta-analysis was to determine the overall accuracy of IP-10 in the diagnosis of TB. A systematic review of studies published in English from Medline, Embase and Cochrane Library was conducted and the data concerning the accuracy of IP-10 in the diagnosis of TB were pooled. The methodological quality of each study was assessed by QUADAS (quality assessment for studies of diagnostic accuracy). Statistical analysis was performed by employing Meta-Disc 1.4 soft-ware and STATA. The overall test performance was summarized using receiver operating characteristic curves. Selleck FG4592 14 studies, based on 2075 subjects, met the inclusion criteria. The summary estimates for IP-10 in the diagnosis of TB were: sensitivity 0.73 (95% CI, 0.71-0.76), specificity 0.83 (95% CI, 0.81-0.86), positive likelihood ratio 7.08 (95% CI, 3.94-12.72), negative likelihood ratio

0.26 (95% CI, 0.20-0.35) and diagnostic odds ratio 29.50 (95% CI, 14.43-60.30), and the area under the curve was 0.88. Our findings suggest that IP-10 may improve the accuracy of TB diagnosis, while the results of IP-10 assays should be interpreted in parallel with conventional test results and other clinical findings.”
“Purpose: In aphasic patients, some studies have already emphasized the efficacy of transcranial direct current stimulation (tDCS) during the treatment of noun retrieval deficits. To date, in the same population, there are have been no studies addressing tDCS effects in the recovery of verb retrieval deficits. In this study, we wanted to test the potential of tDCS to improve verb production in a group of aphasic patients.

However, when larger filters were used, the responses in the right primary visual cortex reached significance. Often, responses in probabilistically defined areas were significant when both small and large filters, but MK-5108 not intermediate filter widths were applied. This suggests that brain responses can be organized in local clusters of multiple distinct activation foci. Our findings illustrate the potential of multi-scale fMRI analysis to reveal novel features in the spatial organization of human brain responses. Hum Brain Mapp, 2011. (c) 2011 Wiley-Liss, Inc.”
“Background The therapeutic advances in breast cancer have improved the

survival of patients with early disease; however, survival improvement of patients with recurrent disease remains ambiguous. In this 3-deazaneplanocin A retrospective study, we examined whether disparities in survival improvement exist in patients with recurrent breast cancer with distant metastasis.\n\nMethods The survival time of 126 patients who experienced recurrence at distant sites from 1990 through 1996 was compared to that of 195 patients who did from 1997 through 2003.\n\nResults A significant survival improvement was observed in the

patients who experienced recurrence in the period of 1997-2003 in comparison to the other period in the subsets with estrogen receptor (ER)-positive disease, those who received adjuvant hormonal therapy, and those with a disease-free interval (DFI) of 24 months or more. However, no significant survival improvement was observed in each counterpart. The Cyclopamine median survival time (MST) from the first relapse of patients with ER-positive disease in the recurrence period of 1997-2003 was 18.8 months longer than that in the recurrence period of 1990-1996 (46.6 months vs. 27.8 months). The MST of patients with a DFI of 24 months or more in 1997-2003 was 20.3 months longer than that in the other

time period (47.2 months vs. 26.9 months).\n\nConclusion The survival of recurrent breast cancer has improved with disparities. The ER status and the DFI are associated with a survival improvement of women with recurrent breast cancer with distant metastases.”
“Background: Curative interventions delivered by community health workers (CHWs) were introduced to increase access to health services for children less than five years and have previously targeted single illnesses. However, CHWs in the integrated community case management of childhood illnesses strategy adopted in Uganda in 2010 will manage multiple illnesses. There is little documentation about the performance of CHWs in the management of multiple illnesses. This study compared the performance of CHWs managing malaria and pneumonia with performance of CHWs managing malaria alone in eastern Uganda and the factors influencing performance.\n\nMethods: A mixed methods study was conducted among 125 CHWs providing either dual malaria and pneumonia management or malaria management alone for children aged four to 59 months.

In the proposed algorithm, the sparse solution is searched iteratively in the 2D solution space and then updated by gradient descent of the total variation (TV) and bivariate shrinkage in the dual-tree discrete wavelet transform (DDWT) domain. Numerous experiments are performed on several natural images. Compared with several state-of-the-art reconstruction algorithms, the proposed algorithm is more efficient and robust, not only yielding higher peak-signal-to-noise ratio but also reconstructing images of better subjective

visual quality. (C) 2014 Elsevier B.V. All rights reserved.”
“Cocaine-and amphetamine-regulated transcript (CART) peptide is implicated in the control of avian energy balance, however, the structure BAY 73-4506 in vitro and expression of CART gene(s) remains largely unknown in birds. Here, we cloned and characterized two CART genes (named cCART1 and cCART2) in chickens. The cloned cCART1 is predicted to generate two bioactive peptides, FK228 solubility dmso cCART1(42-89) and cCART1(49-89), which share high amino acid sequence identity (94-98%) with their mammalian counterparts, while the novel cCART2 may produce a bioactive peptide cCART2(51-91) with 59% identity

to cCART1. Interestingly, quantitative RT-PCR revealed that cCART1 is predominantly expressed in the anterior pituitary and less abundantly in the hypothalamus. In accordance with this finding, cCART1 peptide was easily detected in the anterior pituitary by Western blot, and its secretion from chick pituitaries incubated in vitro was enhanced by ionomycin and forskolin treatment, indicating that cCART1 is a novel peptide hormone produced by the anterior pituitary. Moreover, cCART1 mRNA expression in both the pituitary and hypothalamus is down-regulated by 48-h fasting, suggesting its expression is affected by energy status. Unlike cCART1, cCART2 is only weakly expressed in most tissues examined by RT-PCR, implying a less significant role of cCART2 in AZD1480 in vivo chickens. As in chickens, 2 or more CART genes, likely generated by gene and

genome duplication event(s), were also identified in other non-mammalian vertebrate species including coelacanth. Collectively, the identification and characterization of CART genes in birds helps to uncover the roles of CART peptide(s) in vertebrates and provides clues to the evolutionary history of vertebrate CART genes.”
“In mitochondria, two mono heme c-type cytochromes are essential electron shuttles of the respiratory chain. They are characterized by the covalent attachment of their heme C to a CXXCH motif in the apoproteins. This post-translational modification occurs in the intermembrane space compartment. Dedicated assembly pathways have evolved to achieve this chemical reaction that requires a strict reducing environment. In mitochondria, two unrelated machineries operate, the rather simple System III in yeast and animals and System I in plants and some protozoans.

66, 95% CI 0.74-3.74). The meta-analysis indicated the significant association of +869T/C, but not +915G/C polymorphism with hypertension susceptibility. However, given the limited sample size, the associations warrant further investigation.”
“Non-invasive temperature measurement of tissues deep inside the body has great potential for clinical applications, such as temperature monitoring during thermal therapy and early diagnosis of diseases. We developed a novel method for both temperature estimation and thermal mapping that uses ultrasound

B-mode radio-frequency data. The proposed method is a hybrid that combines elements of physical and statistical models to achieve higher precision and resolution of temperature XMU-MP-1 purchase variations and distribution. We propose a dimensionless combined index (CI) that combines the echo shift differential and signal intensity difference

with a weighting factor relative to the distance from the heat source. In vitro experiments verified that the combined index has a strong linear relationship with temperature variation and can be used to effectively estimate temperature with an average relative error <5%. This algorithm provides an alternative for imaging guidance-based techniques during thermal therapy INCB024360 supplier and could easily be integrated into existing ultrasound systems. (C) 2014 World Federation for Ultrasound in Medicine & Biology.”
“Purpose. – Surgery is the treatment of choice for localized uterine sarcomas. We conducted a retrospective study to define prognostic factors.\n\nPatients and methods. – We studied 111 cases of patients treated by adjuvant radiotherapy for uterine sarcoma in seven French centers. The median decline was 31 months. We conducted a univariate analysis to identify factors correlated with local recurrence. The statistically significant factors were studied in multivariate analysis by Cox model.\n\nResults. – The median dose of external beam radiotherapy

was 45 Gy. Forty-three percent of patients had vaginal vault brachytherapy and 21% chemotherapy. Only 6.3% of patients had complications of acute grade III and 8.1% of long-term sequelae of radiotherapy. The survival rate at 5 years was 74.6%. They noted 12.6% of isolated selleck chemicals llc locoregional recurrences, against 29.7% for distant recurrences, 80% were pulmonary. Factors correlated with the risk of locoregional relapse were menopausal status (P=0.045) and surgical margins suspicious or not healthy (P=0.0095). The chemotherapy did not improve overall survival or disease free survival but the numbers were low.\n\nConclusion. – The postoperative radiotherapy provides good local control in this disease. Brachytherapy is sometimes done, but it does not improve local control. Chemotherapy is not a standard localized stage but the rate of metastatic recurrence calls for the development of strategies involving systemic treatment with radiotherapy. (C) 2010 Societe francaise de radiotherapie oncologique (SFRO). Published by Elsevier Masson SAS.